(PDF) Pilot study of the efficacy and safety of lettuce seed oil in …

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• In this study, we evaluated the sedative and hypnotic effects of L. sativa in patients suffering from insomnia. Sixty patients suffering from insomnia with or without anxiety were randomized to receive capsules containing L. sativa seed oil 1000 mg (n = 30) or placebo (n = 30). All patients were asked to complete a verbal questionnaire before the start of the trial and 1 week after starting treatment. Improvements in the modified State-Trait Anxiety Inventory and the Sleep rating scale scores were significantly greater in patients receiving L. sativa seed oil compared with those on placebo (P < 0.05).